Covid 7/20/20 | COVID 19 Information Page

Good news day….

Lets start with a cool quick video to demonstrate how the covid infection occur. I would add that its not just coughing or sneezing that is causing others to get infected – but talking and singing can also induce increase viral load to get others infected. https://www.technologynetworks.com/cell-science/videos/how-the-novel-coronavirus-infects-a-cell-science-simplified-337534#.

Protein treatment trial with very good results – https://www.bbc.com/news/health-53467022

“The treatment from Southampton-based biotech Synairgen uses a protein called interferon beta which the body produces when it gets a viral infection.

The protein is inhaled directly into the lungs of patients with coronavirus, using a nebuliser, in the hope that it will stimulate an immune response.

The initial findings suggest the treatment cut the odds of a Covid-19 patient in hospital developing severe disease – such as requiring ventilation – by 79%.

Patients were two to three times more likely to recover to the point where everyday activities were not compromised by their illness, Synairgen claims.”

“It said the trial also indicated "very significant" reductions in breathlessness among patients who received the treatment.

In addition, the average time patients spent in hospital is said to have been reduced by a third, for those receiving the new drug – down from an average of nine days to six days.”

“The double-blind trial involved 101 volunteers who had been admitted for treatment at nine UK hospitals for Covid-19 infections.”

“It is possible it could be given emergency approval, as the anti-viral drug remdesivir was in May”

“Interferon beta is part of the body’s first line of defence against viruses, warning it to expect a viral attack.

The coronavirus seems to suppress its production as part of its strategy to evade our immune systems.

The new drug is a special formulation of interferon beta delivered directly to the airways via a nebuliser which makes the protein into an aerosol.

The idea is that a direct dose of the protein in the lungs will trigger a stronger anti-viral response, even in patients whose immune systems are already weak.

Interferon beta is commonly used in the treatment of multiple sclerosis.

Previous clinical trials conducted by Synairgen have shown that it can stimulate an immune response and that patients with asthma and other chronic lung conditions can comfortably tolerate the treatment.”

Another pre-treatment option shown to be effective – over the counter product – https://www.cnbctv18.com/healthcare/coronavirus-treatment-coldzyme-mouth-spray-sars-cov-2-covid-19-enzymatica-6386481.htm

“Swedish life science company Enzymatica has announced that the preliminary results of an in vitro study showing the ability of the mouth spray ColdZyme to deactivate SARS-CoV-2, the virus causing the COVID-19 pandemic. The study demonstrated that ColdZyme deactivates SARS-CoV-2 coronavirus by 98.3 percent.”

“The medical device ColdZyme is a mouth spray that forms a barrier in the oral cavity against common cold viruses. The barrier solution of the device is mainly composed of glycerol and Atlantic cod trypsin.

“The goal of the present study was to determine the ability of ColdZyme to deactivate SARS-CoV-2 known to cause the COVID-19 pandemic. A virucidal efficacy suspension test was conducted using ColdZyme against SARS-CoV-2. ColdZyme deactivated SARS-CoV-2 by 98.3% (1.76 log10) in 20 minutes.

"Furthermore, no cytotoxicity was detected for ColdZyme at any dilution tested. The study was conducted by the US company Microbac Laboratories Inc – an independent, accredited and certified laboratory,” the company statement said.”

I already checked not available on Amazon….sold out on ebay….

Here is another option that’s over the counter which already is taken by many but for some reason never made the media – they didn’t do a double blind either…- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211589/

“A number of drugs have been proposed as treatments to prevent or reduce the severity of a COVID-19 infection. One agent that has been suggested to be potentially useful in this regard is the endogenously synthesized molecule, melatonin [[3], [4], [5], [6], [7]]. Melatonin was initially discovered in and thought to be exclusively a product of the vertebrate pineal gland. However, in consideration of the identification of melatonin in prokaryotic bacteria [8], from which mitochondria evolved (the endosymbiotic theory) and the uncommonly high levels of assayable melatonin in mitochondria [9], it was speculated and eventually documented that this indoleamine is synthesized in this organelle [10]. Given that most cells (a few exceptions) contain mitochondria, it is now believed that melatonin production occurs in most cells in all organisms. This has also been specifically demonstrated in human lung monocytes/macrophages”

“Because of melatonin’s potent antioxidant and anti-inflammatory activities, it would normally reduce the highly proinflammatory cytokine storm and neutralize the generated free radicals thereby preserving cellular integrity and preventing lung damage. In the absence of acetyl-coenzyme A, mitochondrial melatonin is no longer available to combat the inflammatory response or to neutralize the generated reactive oxygen species and the massive damage that occurs in the respiratory tree resulting in the primary signs of COVID-19 disease. Importantly, endogenous melatonin production diminishes markedly with age especially in frail older individuals. This is consistent with the more serious nature of a COVID-19 infection in the elderly.”

“Given the above information, the use of supplemental melatonin as a treatment to overcome a COVID-19 infection is justified. Exogenously administered melatonin reverses aerobic glycolysis by repressing both HIF-1α and mTOR thereby disinhibiting PDC activity and allowing acetyl-coenzyme A synthesis which also ensures locally-produced melatonin production”

“The anti-inflammatory and antioxidant actions of melatonin in protecting the lungs from damage in many experimental models that involve inflammation or oxidative stress (or both) is well documented [14]. Moreover, melatonin has anti-viral actions against viruses other than COVID-19 [15,16]. The collective data, in addition to its very high safety profile, indicate that melatonin would be effective as a treatment for COVID-19 and support the recommendation of the published reports that encourage its use for this purpose [[3], [4], [5], [6], [7]]. Melatonin is inexpensive, non-toxic over a very wide dose range, has a long shelf-life and can be self-administered which is a major advantage when large numbers of individuals are involved. Thus, the use of melatonin to mitigate the COVID-19 pandemic would be feasible and a socially-responsible measure to attempt.”

Looks like I will try adding this to my Vitamin C, D, and Zinc – better sleep will be ancillary benefit hopefully….

On the vaccine front – Russia is pushing through – but what good Russian article doesn’t include hacking – https://fortune.com/2020/07/20/covid-vaccine-russia-approach/

“A top Russian official said his country could roll out a vaccine against COVID-19 as soon as September, while denying accusations that hackers working for the country’s intelligence agency tried to steal sensitive data from rival researchers in the U.K., U.S. and Canada.”

“President Vladimir Putin has made finding a vaccine a top priority. Russia has recorded more than 750,000 COVID-19 cases, making it the fourth most-affected country in the world. In Russia’s race to be the first to find a vaccine against COVID-19, it’s taking an approach that would be shunned in other countries, claiming it will know in just three months of trials whether its leading candidate works. If Russia proclaims success in the hunt for a vaccine before other candidates, it could create a world of dueling vaccines and geopolitical battles over who gets supplies.”

“Dmitriev said he’s so confident in Russia’s leading vaccine candidate that he’s taken it himself and had his whole family vaccinated, including his parents, who are in their seventies. The vaccine, financed by RDIF and developed by the state-backed Gamaleya Institute in Moscow, has completed a phase 1 trial in 50 people, all of whom are members of the Russian military. The institute hasn’t published results.”

“In another unusual move, Dmitriev said the vaccine has been given to “a significant” number of volunteers, both as part of and outside the formal trial. The director of the Gamaleya Institute said he and some of his staff tried the vaccine on themselves before the official trials started, RIA Novosti reported in May. Analysts have questioned Russia’s rushed unorthodox approach.”

“Russia, however, does have a track record developing vaccines using adenoviruses. It devised an Ebola vaccine using similar technology which is licensed in Russia for emergency use and which is expected to be deployes soon in the Congo. And Russia has been increasingly active in promoting its vaccine-making expertise in Africa. The Russian government together with United Company RUSAL opened the Russian-Guinean Research Center for Epidemiology and Prevention of Infectious Diseases in 2014 in Guinea.”

Wow how patriotic so many volunteers.

Miracles do happen….IF we look at the ICU data from the Texas Human and Health Services on July 16th there was only 71 ICU beds left in the Houston Trauma Service Area. This had fallen since July 3rd from 194 – over 9 beds a day – from confirmations rising 34108 to 51959 – 17851 (1373 per day). Death rose 122 (9/day) . Since July 16th confirmation grew to 55743 yesterday – a rise of 3784 (1261/day). In that time the ICU bed availability actually rose from 71 to 100 beds available with death only rising from 509 to 536 (9/day).

Another great Sunday reporting…just not real….Interesting to observe fatality rates do not have much economic correlation. Holds well for my AC hypothesis given poorer regions have no choice but to open windows.