Covid 7/25/20

I will start with the feel good stuff…

94% detection positive rate from dogs trained to detect covid-19 – https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05281-3

“These preliminary findings indicate that trained detection dogs can identify respiratory secretion samples from hospitalised and clinically diseased SARS-CoV-2 infected individuals by discriminating between samples from SARS-CoV-2 infected patients and negative controls. This data may form the basis for the reliable screening method of SARS-CoV-2 infected people.”

“The dogs were able to discriminate between samples of infected (positive) and non-infected (negative) individuals with average diagnostic sensitivity of 82.63% (95% confidence interval [CI]: 82.02–83.24%) and specificity of 96.35% (95% CI: 96.31–96.39%). During the presentation of 1012 randomised samples, the dogs achieved an overall average detection rate of 94% (±3.4%) with 157 correct indications of positive, 792 correct rejections of negative, 33 incorrect indications of negative or incorrect rejections of 30 positive sample presentations.”

This needs to be fast tracked – easy to station dogs in front of schools and public spaces – and who doesn’t love seeing a dog – Mans best friend! The speed and the volume that can be processed in little time allows the efficacy buffer to be drop – 94% is good for me for this purpose vs. $99 per person 2-7 day result and intrusive stick into your nasal cavity limited volume. Lets hope pharma doesn’t try to squash this as this will drop the testing demand – and lets hope someone isn’t in favor/mentions this or else media will crush it….

Another good news you will recover your sense of smell after you recover from covid as it does not directly attack the neurons buts the cells supporting the neurons – https://advances.sciencemag.org/content/early/2020/07/24/sciadv.abc5801.1

“primary infection of non-neuronal cell types — rather than sensory or bulb neurons — may be responsible for anosmia and related disturbances in odor perception in COVID-19 patients.”

I am sure this was censored greatly but the candid discussion seemed to be genuine from the lead scientist that studies bat coronavirus at the Wuhan Institute of Virology – Shi Zhengli – https://www.sciencemag.org/news/2020/07/trump-owes-us-apology-chinese-scientist-center-covid-19-origin-theories-speaks-out?

“She and her colleagues discovered the virus in late 2019, she says, in samples from patients who had a pneumonia of unknown origin. “Before that, we had never been in contact with or studied this virus, nor did we know of its existence,” Shi wrote.”

“Yet the possibility that her lab had played a role worried Shi, she revealed in a March Scientific American profile that briefly touched on origin questions. “She frantically went through her own laboratory’s records from the past few years to check for any mishandling of experimental materials, especially during disposal,” the story said. None of the sequences of bat viruses her lab had found closely matched SARS-CoV-2, the article noted. “That really took a load off my mind,” she told Scientific American. “I had not slept a wink for days.”

Interview pdf – https://www.sciencemag.org/sites/default/files/Shi%20Zhengli%20Q%26A.pdf

“When and where the earliest cross-species transmission of SARS-CoV-2 occurred from

the intermediate host to humans has not been scientifically uncovered yet. We know from

historical experience like HIV that the places where big emerging diseases first break out

usually are not their place of origin (where the spillover originally happened). Tracing the

origin of a virus is a very challenging scientific task. As for the origin and transmission routes

2

of SARS-CoV-2, it needs a pioneering vision, and the collective efforts of scientists all around

the world, and it needs time as well.

We have done bat virus surveillance in Hubei Province for many years, but have not

found that bats in Wuhan or even the wider Hubei Province carry any coronaviruses that are

closely related to SARS-CoV-2. I don’t think the spillover from bats to humans occurred in

Wuhan or in Hubei Province.

I guess you are referring to the bat cave in Tongguan town in Mojiang county of Yunnan

Province. To date, none of nearby residents is infected with coronaviruses. Thus the claim that

the so-called "patient zero" was living near the mining area and then went to Wuhan is false.”

“We detected SARS-CoV-2 nucleic acids in environmental samples from

sources such as rolling door handles, the ground and sewage in that market, but we did not

detect any SARS-CoV-2 nucleic acids in frozen animal samples. The Huanan seafood market

may just be a crowded location where a cluster of early novel coronavirus patients were

found.”

“The results of our tests of SARS-CoV-2 antibodies in cat sera, collected in Wuhan after

the COVID-19 outbreak, revealed that the infection rate and antibody titers of SARS-CoV-2 in

house cats was higher than in stray cats. So I think the SARS-CoV-2 infections in cats were very

likely to have been transmitted by humans.”

“: We first received the clinical samples of SARS-CoV-2 on December 30 2019, which

were called back then samples of “pneumonia with unknown etiology”. Subsequently, we

rapidly conducted research in parallel with other domestic institutions, and quickly identified

the pathogen. The complete genome sequence of SARS-CoV-2 was submitted and published

via WHO on January 12. Before that, we had never been in contact with or studied this virus,

nor did we know of its existence.”

“To date, no pathogen leaks or personnel

infection accidents have occurred.”

“We have only isolated three strains of live SARS-related coronaviruses (SARSr-CoV)

from bats, which shared 95-96% genome sequence similarity with SARS-CoV and less than 80%

similarity with SARS-CoV-2”

“We isolated viruses or extracted virus RNA from biological samples in the lab. The

sequencing was done mostly in Wuhan.”

“Recently we tested the sera from all staff and students

in the lab and nobody is infected by either bat SARSr-CoV or SARS-CoV-2. To date, there is

"zero infection" of all staff and students in our institute.”

“Ra4991 is the ID for a bat sample while RaTG13 is the ID for the coronavirus detected

in the sample. We changed the name as we wanted it to reflect the time and location for the

sample collection. 13 means it was collected in 2013, and TG is the abbreviation of Tongguan

town, the location where the sample was collected.”

“Over the past 20 years, coronaviruses have been disrupting and impacting human lives

and economies. Here, I would like to make an appeal to the international community to

strengthen international cooperation on research into the origins of emerging viruses. I hope

scientists around the world can stand together and work together. The purpose of the search

for the origin of a virus is to prevent the recurrence of similar outbreaks which will harm

human society, and in this way, we can respond more effectively when an outbreak happens.”

Oh crap its still 2020 – https://www.usatoday.com/story/news/health/2020/07/24/cdc-salmonella-outbreak-growing-rapidly-cases-23-states/5505593002/

“CDC: ‘Rapidly growing’ Salmonella outbreak has hit nearly 2 dozen states, source unknown”

What BS reporting and statements being made and perpetuated in press is just really amazingly incredulous – https://www.axios.com/birx-coronavirus-california-florida-texas-e68e3f75-3765-4fbd-b98f-3dad800d5753.html

“Dr. Deborah Birx, the coordinator of the White House coronavirus task force, told NBC’s "Today" on Friday that coronavirus surges in California, Florida and Texas have left the U.S. with "essentially three New Yorks."”

Really? SO What metric are we making that claim on? Thank God it’s a false statement – as NY data is really out there as a worldwide outlier – systematic screw up happened – or data issue – no doubt. In order to compare we had to pick a ramp up moment in time and graph it accordingly in time. The cutoff below is when the 7 day moving average daily death was greater than 75. For NY that began back in late March – For CA Mid April – For AZ FL and TX Early to Mid July…..Like I noted before after that point NY soared to over 200 deaths a day in less than a week (4/1/20) and then less than 2 weeks >500 deaths a day (4/7/20) AND that was with a SHELTER in place March 20th! ONE could easily argue – perhaps with wrong causation/correlation – the data shows that Shelter in place INCREASED deaths! As noted in the reports spread is most likely happening at the home front – shelter in place could exacerbate the situation if not airing out the home. Viral load reaches a point of infection and its game over in terms of staying not sick. Going in and out of home does cause some airing of the home and reduces your viral load activity throughout the day.

County view also shows the same picture as in the state view – NYC is an outlier – their policy/responses killed people in excess that should have happened AND/OR the data is wrong. No other region in world spiked over 1000 deaths a day! Easy to say treatment has improved but there were regions and countries that actually had the issue earlier and they never got that bad China, S. Korea, Japan, Italy, Spain, France….

Peru back down to only reporting 189 deaths – US leads death at 1242. Very important to note is Mexico and their high fatality rates. Note Mexico unlike Brazil is not dispersing HCQ under the guidance from WHO. Brazil fatality rate 3X lower.

Texas leads in death at 168

TX deaths you really need to figure out where because its not really occurring at the population or where the confirmations are occurring. Hidalgo county leads again at 33. I had a discussion with someone who came from a Funeral down south and she had spoken to the medical people down there and what is happening there are many coming from Mexico seeking help and they do not refuse them. The high fatality rates in Mexico one can see why you would want to come to the US. However these numbers are causing a skew in TX data. By the time they arrive in the US they are likely in a bad situation.

Mexico has the highest current fatality rate other than the data revision from Peru yesterday – running at 11.3%