Covid 9/25/20 | COVID 19 Information Page

It would seem Dr. Fauci sounds like he is known about things but only mentions them after it gets some press – now we are talking about the Immune system / Tcells – which has been emphasized on the blog for months. https://amp.mcclatchydc.com/news/coronavirus/article244852012.html?

““One of the things that I don’t think has been emphasized very much at all during the attempt to address, scientifically, the COVID-19 outbreak, and vaccine development and testing, is that we’ve been focusing very exclusively on the antibody test,” Fauci told McClatchy in a recent interview. “There’s another equally important component of the immune system.”

The study, funded by the National Institute of Allergy and Infectious Diseases which Fauci heads, is one of the first to identify T cell “cross reactivity” in individuals who have previously been exposed to one of the four endemic coronavirus strains, SARS or MERS.”

““If you look at it metaphorically as an army with different levels of defense, the antibodies prevent the virus from getting in. So that’s kind of like the first line of defense,” Fauci explained. “For those viruses that do escape and infect some cells, the T cells come in and kill the cells that are infected or block them.””

“Fauci noted that, while T cells last much longer than antibodies, they do not last forever. The more recently an individual was infected with another type of coronavirus, the greater likelihood of some protection from COVID-19.”

““It’s sort of like a one-two punch,” Fauci said. “It’s conceivable that the T cells that you’ve made in response a couple of years ago — three, four, five years ago — when you were exposed to a relatively benign coronavirus that causes the common cold, could actually hang around, and when you’re exposed to the SARS-Coronavirus-2, could have some degree of protection,” he said, referring to the novel coronavirus.”

“Dr. Shane Crotty, a virologist at the La Jolla Institute for Immunology and senior author on the Science study, said in an interview that the findings could mean that individuals with T cell memory from common colds are having less severe responses to COVID-19 exposure, with their immune systems responding to the new infection more quickly.

“At least part of that immune memory is from people’s immune systems seeing common cold coronaviruses before,” Crotty said. “Most people have had those four common cold coronaviruses some time in their life, and about half of people have immune memory that cross-reacts between those common cold coronaviruses and this new coronavirus.”

The initial findings on T cell memory are already helping global leaders in public health better understand why some regions of the world have been hit harder by the COVID-19 pandemic than others.

Bill Gates, co-founder of Microsoft and of the Bill & Melinda Gates Foundation, told CNN over the weekend that “related coronavirus exposure” has begun to explain the regional discrepancies.”

So why spend so much on a vaccine discovery vs. discussion of reducing the hand sanitizer and ultraclean lifestyle? How about getting “vaccinated” by getting a common cold – ridiculous/preposterous you say? Jun 7th 2018 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124400/

“Here, we showed that nasal inoculation of murine coronavirus (CoV) in the absence of direct lung infection primes the lung immune environment by recruiting activated monocytes (Ly6C+ inflammatory monocytes) and NK cells into the lungs. Unlike infiltration of these cells into directly infected lungs, a process that requires type I IFN signaling, nasally induced infiltration of Ly6C+ inflammatory monocytes into the lungs is IFN-I independent. These activated macrophages ingested antigen and migrated to pulmonary lymph nodes, and enhanced both innate and adaptive immunity after heterologous virus infection. Clinically, such nasal-only inoculation of MHV-1 failed to cause pneumonia but significantly reduced mortality and morbidity of lethal pneumonia caused by severe acute respiratory syndrome CoV (SARS-CoV) or influenza A virus. Together, the data indicate that the nose and upper airway remotely prime the lung immunity to protect the lungs from direct viral infections.”

“In order to examine such effects, we intranasally infected BALB/c mice with a pneumotropic murine coronavirus (CoV) delivered in a very small volume (1 μl in each nostril, 2% of normal inoculate volume) to avoid aspiration. We failed to recover any virus in the lungs during the course of the experiment using either real-time quantitative RT-PCR (qRT-PCR) or virus titration, and lung disease was absent. Strikingly, such limited local nasal infection significantly reduced the mortality rates after challenge with 2 heterologous pathogenic respiratory viruses, SARS-CoV (from 100% to 0%) and IAV (from 100% to 60%) and reduced clinical disease.”

“In summary, we demonstrate that nasal exposure to coronavirus remotely primes lung immunity in the absence of direct lung infection, and that such priming provides effective protection against subsequent lethal viral infection in the lungs. Our data reveal that early exposure to pathogens in the nose and upper airways can immunologically prepare the lungs for more rapid initiation of innate and adaptive immune response against homologous and heterologous infection.”

Shocking perhaps but I think it has been quite logical that the immune system requires continuous use else like anything else in the body it weakens. Common cold is actually a workout for the immune system – avoidance of the common cold weakens the immune system.

Concern about the side effects of the common cold vs. side effects of a vaccine rushed to be developed? https://southernmarylandchronicle.com/2020/09/24/nih-very-concerned-about-serious-side-effect-in-coronavirus-vaccine-trial/

“The Food and Drug Administration is weighing whether to follow British regulators in resuming a coronavirus vaccine trial that was halted when a participant suffered spinal cord damage, even as the National Institutes of Health has launched an investigation of the case.”

“A great deal of uncertainty remains about what happened to the unnamed patient, to the frustration of those avidly following the progress of vaccine testing. AstraZeneca, which is running the global trial of the vaccine it produced with Oxford University, said the trial volunteer recovered from severe inflammation of the spinal cord and is no longer hospitalized.

AstraZeneca has not confirmed that the patient was afflicted with transverse myelitis, but Nath and another neurologist said they understood this to be the case. Transverse myelitis produces a set of symptoms involving inflammation along the spinal cord that can cause pain, muscle weakness and paralysis”

“A volunteer in an earlier phase of the AstraZeneca trial experienced a similar side effect, but investigators discovered she had multiple sclerosis that was unrelated to the vaccination, according to Dr. Elliot Frohman, director of the Multiple Sclerosis & Neuroimmunology Center at the University of Texas.”

“In 1976, a massive swine flu vaccination program was halted when doctors began diagnosing a similar disorder, Guillain-Barré syndrome, in people who received the vaccine. At the time no one knew how common GBS was, so it was difficult to tell whether the episodes were related to the vaccine.

Eventually, scientists found that the vaccine increased the risk of the disorder by an additional one case among every 100,000 vaccinated patients. Typical seasonal flu vaccination raises the risk of GBS in about one additional case in every 1 million people.”

“If the AstraZeneca vaccine fails, the U.S. government is supporting six other COVID vaccines in the hope at least one will succeed. The potential problems with the AstraZeneca vaccine show this to be a wise investment, Adalja said.”

Looks like another risk/reward calculation that each individual needs to make IF they continue with this vaccine. Transverse Myelitis certainly does not sound good – pain muscle weakness and paralysis – ugh. Now they believe 1/100,000 – IF you are young there is decent odds it will asymptomatic and better yet if you can hold no comorbidity you are all good. Would you like to take a vaccine with the potential of going through what seems miserable with a 1/100000 chance?

For some good news – lets just ditch these stupid test that take hours/days to get result and look to mans best friend – https://amp.theguardian.com/world/2020/sep/24/close-to-100-accuracy-airport-enlists-sniffer-dogs-to-test-for-covid-19

“In the university’s preliminary tests, dogs – which have been successfully used to detect diseases such as cancer and diabetes – were able to identify the virus with nearly 100% accuracy, even days before before a patient developed symptoms.”

“Dogs are also able to identify Covid-19 from a much smaller molecular sample than PCR tests, Helsinki airport said, needing only 10-100 molecules to detect the presence of the virus compared with the 18m needed by laboratory equipment.”

“Authorities in Vantaa, the city where Helsinki’s international airport is located, said the pilot programme, which is due to last four months, was costing €300,000 (£274,000) , which it said was significantly lower than for laboratory-based testing methods.

Although Covid-19 is known to infect mink and cats, dogs do not have the receptors necessary for the virus to readily gain a foothold and do not appear to be easily infected, according to Hielm-Björkman. There is no evidence that they can transmit the virus to people or other animals.”

US death under 1K in the middle of the weak – impressive….Brazil and India over 1K