Covid 11/21/20 | COVID 19 Information Page

Covid19mathblog.com

So the WORSE county of recent in terms of increasing confirmation and death (see below 30 day sum charts) is traveling – https://www.nbcchicago.com/news/local/crowds-seen-at-ohare-as-travelers-depart-chicago-ahead-of-thanksgiving-holiday/2376658/

In general not pro quarantine everyone but certainly should do something about hotspots? – AND who best to deal with local hotspots – State and Local officials – what are they doing in Cook County IL – exporting problem? Something should happen when you are the worse in the nation – this should also create a checks and balance from counties over reporting – there needs to be impacts when the numbers are out there.

Once again it is about our immune system – we are not helpless we can be accountable – there are ways to boost immune system – here they note the MMR vaccine – https://mbio.asm.org/content/11/6/e02628-20

“There was a significant inverse correlation (rs = −0.71, P < 0.001) between mumps virus titers (mumps titers) and COVID-19 severity within the MMR II group. There were no significant correlations between mumps titers and severity in the comparison group, between mumps titers and age in the MMR II group, or between severity and measles or rubella titers in either group. Within the MMR II group, mumps titers of 134 to 300 arbitrary units (AU)/ml (n = 8) were found only in those who were functionally immune or asymptomatic; all with mild symptoms had mumps titers below 134 AU/ml (n = 17); all with moderate symptoms had mumps titers below 75 AU/ml (n = 11); all who had been hospitalized and had required oxygen had mumps titers below 32 AU/ml (n = 5). Our results demonstrate that there is a significant inverse correlation between mumps titers from MMR II and COVID-19 severity.”

“First, young children are largely spared from severe disease. Second, numerous countries have COVID-19 death rates that are as low as 1% of the death rates of other countries. Third, many people, despite prolonged close contact with someone who is COVID-19 positive, never test positive themselves. Fourth, nearly half of people who test positive for COVID-19 are asymptomatic. Some researchers have theorized that the measles-mumps-rubella (MMR) vaccine may be responsible for these disparities. The significance of our study is that it showed that mumps titers related to the MMR II vaccine are significantly and inversely correlated with the severity of COVID-19-related symptoms, supporting the theorized association between the MMR vaccine and COVID-19 severity.”

“The inverse correlation between mumps titers and severity was not age related.”

“COVID-19 case prevalence is seven times lower in young children than in adults.”

“The CDC data that we reviewed indeed indicated that the age of 14 years is the pivot point at which both the incidence of COVID-19-positive cases and the risk of death begin to rise sharply. We acknowledge that the sharp rise in the incidence of cases at age 14 years may also be influenced by other factors; however, this association adds further support to the hypothesis that MMR II-induced immunity may be a significant factor in protecting vaccinated children through age 14 years from COVID-19, in addition to protecting older adults with adequate mumps titers.”

“In the United States, there have been 65% more COVID-19 cases diagnosed in infants less than 12 months of age than in children 2 years of age. The increase in the number of cases in infants less than 12 months of age might also be related to an association between MMR II and COVID-19 because infants do not receive their first MMR II vaccination until 12 to 15 months of age. Those infants who are protected might be protected by transplacentally acquired MMR antibodies lasting up to 6 months of age (14). A study in China further supported age-related associations in children. While COVID-19-positive children aged 1 to 15 years were found to be asymptomatic 3.1% to 6.5% of the time, infants less than 1 year of age in China were asymptomatic only 1.9% of the time. Further, children in that Chinese study who were aged 1 to 15 years had critical COVID-19 illness no more than 0.7% of the time, while those less than 1 year of age had critical illness 1.9% of the time (15).”

“While the associations that we have observed between MMR II and COVID-19 do not prove causation, the significant associations lend further support to the theory that the MMR II vaccine may provide long-term, cross-protective immunity against COVID-19. A possible factor in this protection is the sequence homology between both mumps and measles viruses and the fusion proteins of SARS-CoV-2 and/or the 29% amino acid sequence homology between the rubella virus and Macro (ADP-ribose-1-phosphatase) domains of SARS-CoV-2”

“There are other ways in which the MMR II vaccine may function against COVID-19. Live attenuated vaccines induce forms of nonspecific trained innate immunity that may act against COVID-19. The term “trained innate immunity” is based upon observations made in different infection and vaccination models describing increased resistance to reinfection independent of memory lymphocyte reactivation, resulting in the hypothesis that the innate immune system “remembers” prior infections through cellular epigenetic reprogramming”

Time to get the MMR vaccine booster…. Perhaps advise newborns to get the MMR sooner like in China?

Another amazing jump in confirmation for the US…and unfortunately 1.9K deaths – France second place