Covid19mathblog.com

As noted yesterday the halting of J&J seems very blunt vs. halting for females since all 6 incident females – but nonetheless for 6/7million – strange – all in the benefit of the mRNA vaccine. However lets consider the mRNA – could it be the mRNA causes much more unintended consequence vs. the proven adenovirus mechanism (J&J and Astrazeneca)? Interesting this is written submission to FDA for a concern about the mRNA vaccine by Dr. J Patrick Whelan – Volunteer Assistant Clinical Professor of Microbiology and Immunology Member, Academic Advisory Board, Institute for Advanced Catholic Studies at USC President, Los Angeles Pediatrics Society by the way seems to be democrat given Author of The Catholic Case for Obama Former adviser to Gov. Howard Dean and Democratic National Committee https://www.regulations.gov/document/FDA-2020-N-1898-0246

“I am a pediatric specialist caring for children with the multisystem inflammatory syndrome (MIS-C). I am concerned about the possibility that the new vaccines aimed at creating immunity against the SARS-CoV-2 spike protein (including the mRNA vaccines of Moderna and Pfizer) have the potential to cause microvascular injury to the brain, heart, liver, and kidneys in a way that does not currently appear to be assessed in safety trials of these potential drugs.”

“Magro et al. showed that there is complement-mediated damage even in grossly normal skin of coronavirus-infected individuals (Human Pathology 2020:106:106-116). They have also shown (Magro et al. Annals of Diagnostic Pathology 2021:50 in press ) that ACE-2 receptor expression is highest in the microvasculature of the brain and subcutaneous fat, and to a lesser degree in the liver, kidney, and heart. They have further demonstrated that the coronavirus replicates almost exclusively in the septal capillary endothelial cells of the lungs and the nasopharynx, and that viral lysis and immune destruction of those cells releases viral capsid proteins (or pseudovirions) that travel through the circulation and bind to ACE2 receptors in these other parts of the body leading to mannan-binding lectin complement pathway activation that not only damages the microvascular endothelium but also induces the production of many pro-inflammatory cytokines. Meinhardt et al. (Nature Neuroscience 2020, in press) show that the spike protein in brain endothelial cells is associated with formation of microthrombi (clots), and like Magro et al. do not find viral RNA in brain endothelium. In other words, viral proteins appear to cause tissue damage without actively replicating virus.”

“Is it possible the spike protein itself causes the tissue damage associated with Covid-19? Nuovo et al (in press) have shown that in 13/13 brains from patients with fatal COVID-19, pseudovirions (spike, envelope, and membrane proteins) without viral RNA are present in the endothelia of cerebral microvessels. Furthermore, tail vein injection of the full length S1 spike subunit in mice led to neurologic signs (increased thirst, stressed behavior) not evident in those injected with the S2 subunit. The S1 subunit localizes to the endothelia of microvessels in the mouse brain, and is a potent neurotoxin. So the spike S1 subunit of SARS-CoV-2 alone is capable of being endocytosed by ACE2 positive endothelia in both human and mouse brain, with a concomitant pauci-cellular microencephalitis that may be the basis for the neurologic complications of COVID-19. The Pfizer/BioNTech vaccine (BNT162b2) is composed of an mRNA that produces a membrane-anchored full-length spike protein. The mouse studies suggest that an untruncated form of the S1 protein like this may cause a microvasculopathy in tissues that express much ACE2 receptor. A truncated form of S1 was much less damaging in mice.”

Supporting study to the statements above – also supports thesis that males more likely to get infected vs females – https://www.nature.com/articles/s41593-020-00771-8

“We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood–brain barrier in male mice, was taken up by brain regions and entered the parenchymal brain space. I-S1 was also taken up by the lung, spleen, kidney and liver. Intranasally administered I-S1 also entered the brain, although at levels roughly ten times lower than after intravenous administration”

“These results suggest that enhanced uptake of I-S1 by some tissues could contribute to the increased risk of COVID-19 in males versus females, but not to the risk associated with the APOE4 genotype.”

“many if not most viral proteins themselves can be biologically highly active; for example, gp120 is highly toxic11,12,13,14,15,16,17. Coronavirus spike proteins are often cleaved from the virus by host cell proteases. Once cleaved, coronavirus spike S1 and S2 subunits are not held covalently by disulfide bonds and so S1 could be shed from virions34. It is possible that during infection by SARS-CoV-2, shed S1 is available to cross the BBB, triggering responses in the brain itself, without necessarily involving crossing of intact virus particles. Thus, determining whether S1 crosses the BBB is important for understanding whether SARS-CoV-2 and S1 itself could induce responses in the brain.”

To each his/her own in calculating risk/reward. It is clear the mRNA vaccine is not fully vetted or understood in terms of longterm impact and the mechanism potential unintended consequences. There could be positive unintended consequences too – perhaps protects against common colds too? Still it is murky so IF YOUNG AND HEALTHY – the risk/reward profile shifts drastically when considering mRNA vaccination. It would also make more logical sense to take the more perceived efficacy vaccine IF you are older (less years to worry about longterm impact) and have multiple comorbidities. Personally I was scheduled to take the J&J and feel comfortable taking it if allowed again. mRNA has too many unknowns in my opinion given the alternatives and a healthy lifestyle I try to live. Perhaps the mRNA will become the best medical invention of all time – but no one really knows all the impacts of having a spike protein inserted in your body. I still believe the best medical advice I have read is to live a healthy lifestyle – stick with whole foods reduce sugars/process foods and alcohol.

Amazing India confirmations – can you really test than many people in 1 day! The deaths numbers for India is amazing. I guess if you can survive the first few years in India you are likely someone with a strong immunity – given all the stuff in the environment (mosquitos, pollution, etc..)

India deaths are starting to rise now

MI leads confirmation. MS leads death

Michigan still is the prime concern for the US

Daily vaccinations are still climbing