Covid 8/7/21 | COVID 19 Information Page

Covid19mathblog.com

Vaccination effectiveness wanning this study show effectiveness dropping close to 50%– this study does try to demonstrate that vaccinated people have potentially lower viral load than ones without via Ct testing. Unfortunately demographics not broken out on the Ct to see if other effects causing this. https://spiral.imperial.ac.uk/bitstream/10044/1/90800/2/react1_r13_final_preprint_final.pdf

“After adjusting for age, sex, region, ethnicity and index of multiple

deprivation (IMD) [14], for all swab-positives, we estimated vaccine effectiveness (VE) in

round 12 of 64% (11%, 85%) and 49% (22%, 67%) in round 13. For those with symptoms

we estimated VE of 83% (19%, 97%) in round 12 and 59% (23%, 78%) in round 13.”

One reason to need to break up the Ct demographic because we know for a fact your lifestyle makes a big deal for vaccine effectiveness. In fact we should potentially banned process food for a month to get this virus in control. I would fear less a healthy vaccinated person vs an obese multiple comorbidity vaccinated person. This likely also explains why the numbers are worse in the West world vs. Asia – https://www.npr.org/sections/health-shots/2019/11/24/782079520/excess-weight-can-weaken-the-flu-shot

“But scientists have come to realize that flu vaccines are less effective for people who are overweight or obese. Considering that excess weight affects more than two-thirds of the U.S. adult population, that’s a significant shortcoming.

Researchers are studying why that’s the case, with an eye toward developing better flu vaccines.”

“"The virus is able to grow to higher [concentrations] and spread deeper in your lungs, which is not what you want during an influenza infection," she says.

And people weren’t simply getting sicker — they were also more likely to spread the disease. That has the potential to amplify a flu outbreak.”

Data supporting healthy youth obtaining Covid-19 unless they want to be on vaccines the rest of their lives? – https://insight.jci.org/articles/view/150909

“In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or mild symptomatic SARS-CoV-2 infection. We detected robust IgM, IgG, and IgA antibody responses to a broad array of SARS-CoV-2 antigens at the time of acute infection and 2 and 4 months after acute infection in all participants. Notably, these antibody responses were associated with virus neutralizing activity that was still detectable 4 months after acute infection in 94% of children. Moreover, antibody responses and neutralizing activity in sera from children and adolescents were comparable or superior to those observed in sera from 24 adults with mild symptomatic infection. Taken together, these findings indicate children and adolescents with mild or asymptomatic SARS-CoV-2 infection generate robust and durable humoral immune responses likely contribute to protection from reinfection.”

Potentially another treatment – when will any of these treatment beyond Regeneron get fast tracked? https://www.jpost.com/health-science/covid-90-percent-of-patients-treated-with-new-israeli-drug-discharged-in-5-days-675961

“Some 93% of 90 coronavirus serious patients treated in several Greek hospitals with a new drug developed by a team at Tel Aviv’s Sourasky Medical Center as part of the Phase II trial of the treatment were discharged in five days or fewer.

The Phase II trial confirmed the results of Phase I, which was conducted in Israel last winter and saw 29 out of 30 patients in moderate to serious condition recover within days.”

“Arber and his team, including Dr. Shiran Shapira, developed the drug based on a molecule that the professor has been studying for 25 years called CD24, which is naturally present in the body.

“It is important to remember that 19 out of 20 COVID-19 patients do not need any therapy,” Arber said. “After a window of five to 12 days, some 5% of the patients start to deteriorate.”

“If the results are confirmed, he vowed that the treatment can be made available relatively quickly and at a low cost.”

Another point that natural immunity is superior else why would you try to harvest their antibodies? IF everyone including healthy get the vaccine the ultrapotent antibody perhaps would not be discovered/created. FYI convalescent= (of a person) recovering from an illness or operation. https://science.sciencemag.org/content/early/2021/06/30/science.abh1766

“We identify four receptor-binding domain targeting antibodies from three early-outbreak convalescent donors with potent neutralizing activity against 23 variants including the B.1.1.7, B.1.351, P.1, B.1.429, B.1.526 and B.1.617 VOCs. Two antibodies are ultrapotent, with sub-nanomolar neutralization titers (IC50 0.3 to 11.1 ng/mL; IC80 1.5 to 34.5 ng/mL). We define the structural and functional determinants of binding for all four VOC-targeting antibodies and show that combinations of two antibodies decrease the in vitro generation of escape mutants, suggesting their potential in mitigating resistance development.”

“Our results show that highly potent neutralizing antibodies with activity against VOCs was present in at least 3 of 4 convalescent subjects who had been infected with ancestral variants of SARS-CoV-2”

Indonesia continues to lead the death charts.