Another study to confirm the interaction with the common cold coronavirus and SARS-CoV-2 (virus that causes covid-19) this time focused on B Cells– FYI HCoV is typically the coronavirus that cause the common cold there are are like at least 5 variants of HCoV floating around in society – https://mbio.asm.org/content/11/5/e01991-20

“The idea that circulating HCoVs elicit IgG that cross-reacts with SARS-CoV-2 is supported by the finding that SARS-CoV-2 infection increases IgG titers against the S proteins of multiple HCoVs”

“SARS-CoV-2-reactive memory B cells (MBCs) generated in B cell responses to HCoVs are also likely to be present in non-SARS-CoV-2-exposed individuals. Indeed, MBCs might be more important than preexisting cross-reactive Abs as a source of protection against SARS-CoV-2.”

“MBCs are long-lived cells that continue to provide strong protection when circulating Ab levels wane”

“Notably, 86% of unexposed subjects had IgG against the S2 subunit, reflecting homology with HCoVs, but none had IgG against the highly novel SARS-CoV-2 RBD (6, 8, 24). Abs that target the S2 subunit have been shown to have virus-neutralizing activity, raising the possibility that the presence of preexisting anti-S2 IgG confers some protection against SARS-CoV-2”

“In conclusion, our analysis investigated Ab and MBC immunity to SARS-CoV-2 in unexposed subjects and individuals soon after recovery from SARS-CoV-2 infection. The findings emphasized the novelty of the SARS-CoV-2 S protein RBD in unexposed subjects. However, IgG reactive to the S2 was widespread in unexposed subjects and likely resulted from exposure to HCoVs. Although our approach was unable to directly identify S2-reactive MBCs in the unexposed subjects, we suggest that these cells were present and strongly contributed S2-reactive IgG early in the response to SARS-CoV-2 infection.”

We cannot and should not limit the common cold as it allows “Exercise” for our immune system and the outcome of the common cold is very mild in the grand scheme.

The ONLY proven but not touted enough way to fight covid-19 is to be healthy! Quarantine/lock down seems to not be doing that- In the UK they are gaining weight in a time they need to be getting healthy. – https://covid.joinzoe.com/post/lockdown-weight-gain

“almost a third (29%) of those surveyed gained weight since March 2020.”

“The factors that may have contributed to weight gain during lockdown include increased snacking (35%), decreased levels of physical activity (34%), increased alcohol consumption (27%) and a less healthy diet (19%).”

How about forcing people to eat well and exercise – is that more intrusive than forcing people to not socialize and stay in lock down? Perhaps modification of age lockdown is to change it to health lockdown – initially proposed awhile back – given its easy to test for common comorbidities that would lead to fatal results with covid-19? The good thing for the most part many of those comorbidities can be gone in relatively short time with eating well and exercise. Those not healthy and not going to quarantine/lockdown/wearing mask are adding a large cost to society.

Brazil back on top as the US continues under 1K!

FL leads the US at 74….interestingly to see AZ fall of the map in terms of confirmation.

LA and Miami-Dade tied at 16 to lead all US counties…some 1K+ confirmations in TX counties Harris and Collin

As noted above AZ confirmations have been low – Maricopa has stayed under 400 for quite some time. Death rate in Maricopa coming down now under 9 a day.

Sweden confirmations are slightly rising but unlike all the other European countries their deaths seem to be stabilized at around 2 a day.