Covid 12/7/20

Covid19mathblog.com

BCG studied by Russian scientist and have concluded that there is a positive link. Once again seems like a simple no brainer option given vast experience and knowledge on BCG – at the least you get vaccinated from TB https://theprint.in/health/now-russian-scientists-find-link-between-bcg-vaccine-covid-19-immunity/558384/

“Scientists from St. Petersburg University, Russia, have analysed data detailing Covid-19 spread in several countries to find that “new coronavirus infection occurs more slowly where there is a large percentage of people vaccinated against tuberculosis with the BCG vaccine”.

The effect of the Bacillus Calmette-Guerin (BCG) vaccine on immunity against Covid-19 is currently being investigated across the world, with some earlier studies deriving similar conclusions as well. India is one of the countries where BCG, which guards against tuberculosis, is part of the immunisation programme for children.”

“The researchers from St. Petersburg University added that they “have analysed about 100 academic papers and statistics” on the spread of Covid in different countries to arrive at their conclusion. Their study has been published in the Russian peer-reviewed journal Juvenis scientia.”

Antiviral drug shown to stop covid-19 spread within 24 hours in ferrets – https://www.nature.com/articles/s41564-020-00835-2

“Therapeutic treatment of infected animals with MK-4482/EIDD-2801 twice a day significantly reduced the SARS-CoV-2 load in the upper respiratory tract and completely suppressed spread to untreated contact animals. This study identified oral MK-4482/EIDD-2801 as a promising antiviral countermeasure to break SARS-CoV-2 community transmission chains.”

Antibody test that goes beyond yes and no and actually MEASURES the level of antibodies and tells you – https://www.startribune.com/this-test-can-read-your-level-of-covid-antibodies/573312841/

“A person’s COVID titer (pronounced TIGHT-er) is a measure of the concentration of virus-neutralizing antibodies in their blood. A high-enough titer of the antiviral proteins provides immunity to COVID-19, though researchers are still working to nail down exactly when protection ends.

Taking a vaccine is one way to build up a protective titer, and recovering from COVID-19 is another. Some patients are getting infusions of lab-grown or donated antibodies to increase their titers.

“Based on our knowledge of other viruses, the higher the titer, the more likely you are to have immunity,” said Marc Jenkins, director of the Center for Immunology at the University of Minnesota. “But where the cutoff is [for loss of immunity] is still uncertain.”

Now a $300 blood test made by Imanis Life Sciences in Rochester is offering consumers a quantitative measurement of their neutralizing antibody titers. Multiple such tests could track the decline of antibodies over time.

Unlike most other antibody tests authorized in the United States, Imanis’ Immuno-Cov V2.0 test returns a number that represents the concentration of virus-killing antibodies in the sample, instead of just a “yes” or “no” on whether antibodies were detected.”

“Internal data from Imanis shows that two of 14 people who got their titers measured twice had no detectable neutralizing antibodies after six months, and two more had titers that hovered just above the test’s limit of detection.

Such insights could inform decisions about whether someone needs a COVID-19 vaccine booster shot, especially if they work in a field such as health care, Russell said.

An earlier version of the neutralizing antibody test became available through Mayo Clinic in June.”

“Version 2.0, which became available to the public via physician order online late last month, is run directly by Imanis. It’s a refined and revalidated version of the original, and Imanis made enough testing medium to run 5 million of the second-generation tests at its own lab.

Antibody testing cannot diagnose an active case of COVID-19; that can be done only by polymerase chain reaction (PCR) technology. In Minnesota, another form of testing that looks for viral molecules called “antigens” can provide a probable diagnosis.”

“The Imanis test is designed to emit light inside a laboratory machine when a sample that contains neutralizing antibodies is exposed to an innocuous virus that has been genetically engineered to have coronavirus spikes. Non-neutralizing antibodies don’t trigger the glow.

Imanis senior scientist Rianna Vandergaast said it’s likely that no single magic titer applies to everyone. But eventually people will be able to see where they fall within broad categories such as low, moderate or high titers. And they’ll be able to track change over time.”

Database migration has caused some issues on updates….