Covid19mathblog.com
Do you want to know how thorough phase 3 is – take a look at J&J – in addition its important to note the 65% vs 95% is not clear its apple to apple. If you read the document there is a definition of serious covid which gets to the 85% – in the end its not the calculation of death. There was no death from what I gather so one COULD say the vaccine helped either way….. https://www.jnj.com/coronavirus/covid-19-phase-3-study-clinical-protocol
“Case Definition for Severe/Critical COVID-19
A SARS-CoV-2 positive RT-PCR or molecular test result from any available respiratory tract sample
(eg, nasal swab sample, sputum sample, throat swab sample, saliva sample) or other sample
AND any 1 of the following at any time during the course of observationa
:
Clinical signs at rest indicative of severe systemic illness (respiratory rate ≥30 breaths/minute, heart
rate ≥125 beats/minute, oxygen saturation (SpO2) ≤93% on room air at sea level*, or partial pressure
of oxygen/fraction of inspired oxygen (PaO2/FiO2) <300 mmHg)
* SpO2 criteria will be adjusted according to altitude per the investigator judgement.
Respiratory failure (defined as needing high-flow oxygen, non-invasive ventilation, mechanical
ventilation, or extracorporeal membrane oxygenation [ECMO])
Evidence of shock (defined as systolic blood pressure <90 mmHg, diastolic blood pressure <60 mmHg,
or requiring vasopressors)
Significant acute renal, hepatic, or neurologic dysfunction
Admission to the ICU
Death”
For some reason this study didn’t make much news – HCQ with Zinc and Azithromycin works to reduce covid-19 when treated early – perhaps with Biden people can admit to what is there – risk/reward is asymmetric – https://www.sciencedirect.com/science/article/pii/S0924857920304258?via%3Dihub
“chloroquine and probably HCQ have characteristics of a zinc ionophore resulting in increasing intracellular zinc concentrations [20]. The dose of elementary zinc in this study was similar to doses previously studied to successfully prevent infections in the elderly [45]. The antiviral effects of zinc against a variety of viruses have been demonstrated during the last decades [46]. Zinc, in addition to its role as a general stimulant of antiviral immunity, is known to specifically inhibit coronavirus RNA-dependent RNA polymerase (RdRp) [21]. Based on the ionophore properties of HCQ, it has been hypothesised that zinc may enhance the efficacy of HCQ in treating COVID-19 patients [22]. In addition, zinc might inhibit the serine protease furin [47]. Furin is expressed on endothelial cells, monocytes/macrophages and smooth muscle cells in human atherosclerotic plaques [48] and therefore might play a critical role for the severe cardiovascular complications of COVID-19. As furin might be responsible to favour SARS-CoV-2 spread compared with other Betacoronaviruses [49,50] and as furin inhibition protects from certain viral-dependent infections [51], it may be important to evaluate the potential role of zinc in inhibiting this pathway.”
“Although there is a synergistic antiviral effect between zinc, HCQ and azithromycin, zinc supplementation may be instrumental for the outcome of patient populations with severe clinical courses. Zinc deficiency was confirmed in a large number of healthy elderly [53] and in diabetic patients [54]. In addition, it has been documented that the antihypertensive drugs hydrochlorothiazide, angiotensin-converting enzyme inhibitors and angiotensin 2 receptor antagonists can result in increased urinary excretion of zinc with subsequent systemic zinc deficiency [55]. Age, co-morbidities and relevant co-medications align well with the majority of described COVID-19 patients at high risk, including the risk-stratified population of this analysis. Zinc deficiency might explain why certain patient groups seem not to benefit from HCQ monotherapy. During the 5-day treatment with the triple therapy and during follow-up, no severe adverse events were observed and no cases of cardiac arrhythmia were reported in this general practice, which is in accordance with available safety data for more than 300 000 patients”
CA deaths are high regardless of Covid – almost shows other extra death the same level as covid – so our treatment plan is causing just as much death as covid!
US death back below 4K
CA still leads the US
LA county still leads all counties
LA county data is coming down for confirmation….death is still staying up
