Covid 5/21/20

The CDC has updated its site – and is leaning towards my latest hypothesis in that the spread is not likely from contact. https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/how-covid-spreads.html

“The virus spreads easily between people

How easily a virus spreads from person-to-person can vary. Some viruses are highly contagious, like measles, while other viruses do not spread as easily. Another factor is whether the spread is sustained, which means it goes from person-to-person without stopping.

The virus that causes COVID-19 is spreading very easily and sustainably between people. Information from the ongoing COVID-19 pandemic suggest that this virus is spreading more efficiently than influenza, but not as efficiently as measles, which is highly contagious.

The virus does not spread easily in other ways

COVID-19 is a new disease and we are still learning about how it spreads. It may be possible for COVID-19 to spread in other ways, but these are not thought to be the main ways the virus spreads.

From touching surfaces or objects. It may be possible that a person can get COVID-19 by touching a surface or object that has the virus on it and then touching their own mouth, nose, or possibly their eyes. This is not thought to be the main way the virus spreads, but we are still learning more about this virus.

From animals to people. At this time, the risk of COVID-19 spreading from animals to people is considered to be low. Learn about COVID-19 and pets and other animals.

From people to animals. It appears that the virus that causes COVID-19 can spread from people to animals in some situations. CDC is aware of a small number of pets worldwide, including cats and dogs, reported to be infected with the virus that causes COVID-19, mostly after close contact with people with COVID-19. Learn what you should do if you have pets.”

This is a good thing as then it means just because someone was sick in a room that room is not necessarily completely contaminated e.g. elevator. However IF the person is in the room with you for an extended time period that’s another issue.

This article support Dr. Kory testimony – https://nationalinterest.org/blog/reboot/coronavirus-blocking-deadly-cytokine-storm-key-treating-virus-156086

“The killer is not the virus but the immune response.”

“Cell death – a chess game of sacrifice

I study inflammatory response and cell death, which are two principal components of the innate response. White blood cells called macrophages use a set of sensors to recognize the pathogen and produce proteins called cytokines, which trigger inflammation and recruit other cells of the innate immune system for help. In addition, macrophages instruct the adaptive immune system to learn about the pathogen and ultimately produce antibodies.

To survive within the host, successful pathogens silence the inflammatory response. They do this by blocking the ability of macrophages to release cytokines and alert the rest of the immune system. To counteract the virus’s silencing, infected cells commit suicide, or cell death. Although detrimental at the cellular level, cell death is beneficial at the level of the organism because it stops proliferation of the pathogen.”

“Here’s how an overreaction from the immune system can endanger a person fighting off an infection.

“Some of the proteins that trigger inflammation, named chemokines, alert other immune cells – like neutrophils, which are professional microbe eaters – to convene at the site of infections where they can arrive first and digest the pathogen. Others cytokines – such as interleukin 1b, interleukin 6 and tumor necrosis factor – guide neutrophils from the blood vessels to the infected tissue. These cytokines can increase heartbeat, elevate body temperature, trigger blood clots that trap the pathogen and stimulate the neurons in the brain to modulate body temperature, fever, weight loss and other physiological responses that have evolved to kill the virus.

When the production of these same cytokines is uncontrolled, immunologists describe the situation as a “cytokine storm.” During a cytokine storm, the blood vessels widen further (vasolidation), leading to low blood pressure and widespread blood vessel injury. The storm triggers a flood of white blood cells to enter the lungs, which in turn summon more immune cells that target and kill virus-infected cells. The result of this battle is a stew of fluid and dead cells, and subsequent organ failure.”

“Inhibition of tumor necrosis factor can be achieved with FDA-approved antibody drugs like Remicade or Humira or with a soluble receptor such as Enbrel (originally developed by Bruce Beutler) which binds to tumor necrosis factor and prevents it from triggering inflammation. The global market for tumor necrosis factor inhibitors is US$22 billion.

Drugs that block various cytokines are now in clinical trials to test whether they are effective for stopping the deadly spiral in COVID-19.”

Not sure why he didn’t discuss just using steroids as Dr. Kory suggested – perhaps no $? – 2001 study – https://pubmed.ncbi.nlm.nih.gov/11447379/

“Conclusion: These studies indicate that prednisone suppresses multiple components of allergic airway inflammation, including cell recruitment, adhesion molecule expression or release, airway permeability, and production of cytokines potentially involved in airway immunity or remodeling.”

This reports conclude infected New York rates 20+% – https://www.usnews.com/news/national-news/articles/2020-05-20/new-york-expands-coronavirus-testing-as-state-identifies-hot-spots-in-new-york-city?

“Antibody tests of approximately 8,000 people in New York City revealed an infection rate highest in the Bronx borough of New York City. While the overall positive rate is 19.9% for the city, the Bronx has a positive rate of 34%. Brooklyn has a rate of 29% and Queens has a rate of 25%. Rates in the Manhattan and Staten Island boroughs are 20% and 19%, respectively.”

This would drop the fatality rate down to around 6% vs 11% for NYC.

HCQ preliminary results in India https://m.timesofindia.com/city/mumbai/toll-climbs-to-9-cops-on-hcqs-spared-the-worst/amp_articleshow/75845670.cms?

“Around 10,000 policemen over the age of 40 years were to be given the drug, hydroxychloroquine sulphate (HCQS), which was cleared by the ICMR as a drug with the potential to prevent a novel coronavirus infection. “However, only 4,500 of the policemen are taking the medicine diligently,” said Dr Sanjay Kapote of Apollo Clinics, who arranged for the tablets and their distribution across the police stations.

toll of police personnel who have died in Mumbai in the last 25 days to nine. Meanwhile, on Tuesday, an assistant commissioner of police from the western suburbs tested positive for Covid-19 and has been hospitalised. Three officers attached to Samta Nagar police station in Kandivli (E) have also tested positive.

Dr Kapote said there was no mortality among the 4,500 policemen who took HCQS in Mumbai. “Although some in this group have contracted Covid, they had a mild attack,” he said.”

Evolution – https://www.independent.co.uk/news/wuhan-china-coronavirus-ban-wild-animals-eating-wildlife-trade-markets-a9524606.html?

“Authorities in Wuhan, the epicenter of the coronavirus pandemic, have officially banned the eating of all wild animals”

US deaths 1518. Brazil (876) and Mexico (424) continue to show high death numbers.

Once again NY is the leader at 162 – but IL,PA, MA not far behind.

Interesting to see the 4 corners area of AZ and NM showing up on the county view.

Brazil and Mexico are apparent in the daily death pie chart.

Brazil is about to pass Italy peak 7 day MA death change. Brazil likely over 30+K deaths.